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Shipping & Receiving Extracts All allergen extracts are shipped expedited using a reputable courier under non-refrigerated conditions. It is important to ensure that a member of your staff be available on the day your products are scheduled to arrive to minimize the amount of time the extracts are out of refrigeration. When your supplies arrive,… read more

Analytical Method – ID50EAL (“IDEAL 50”) Standardized potency values were established by a skin test titration study (ID50EAL) using a limited number of patients. “ID50EAL” is an acronym for “Intradermal Dilution for 50 mm sum of Erythema determines the bioequivalent ALlergy units.” This study measured the size of the erythema in allergic patients receiving a… read more

Profilin & Pan-Allergens Cross-reactivity is often seen between unrelated species due to shared minor allergens such as Profilin. A minor allergen is an allergenic protein that has demonstrated clinical sensitivity in a minority of patients in a population. Common allergens that demonstrate clinical sensitivity across unrelated species are known as Pan-Allergens. Profilin is a structual… read more

Major Allergen Characterization The active ingredients of allergenic extracts are the proteins that the immune system responds to. Within an extract, there may be multiple allergenic proteins. Major allergens are those proteins to which at least 50% of a population are sensitized to. Some of these allergens, such as Fel d 1 in cat, are… read more

Standardized Extracts The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between lots and manufacturers of the same extract. Extracts that have been standardized by the FDA include the northern pasture grasses (Timothy, June, Meadow Fescue, Orchard, Redtop, Perennial Rye, Sweet… read more

Diluents & Preservatives When making dilutions from the concentrate vial, a number of diluents can be used. Normal Saline with Phenol (NSP) NSP is the same solution that is used to extract Aqueous extracts. It is a buffered solution of sodium chloride (0.9%) with phenol (0.4%) as a preservative. NSP offers limited stability protection for… read more

Quality Concern – Color Variation Since extracts are produced from biological materials that can be highly variable, the color of one manufactured lot may be different from a previous lot of the same product. An extract’s color comes from the pigmentation found in the source materials, which can vary significantly between lots. Since an extract’s… read more